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LRSS Publications
Alternatives to Animal Testing

01 February 2025

Characterization of the in vitro penetration and first-pass metabolism of genistein and daidzein using human and pig skin explants and Phenion full-thickness skin models
LRSS Publications
Alternatives to Animal Testing

01 February 2025

Effect of vehicle on the in vitro penetration and metabolism of genistein and daidzein in ex vivo skin explants and the Phenion full-thickness skin model
LRSS Publications
Alternatives to Animal Testing

01 July 2024

Use of in vitro ADME methods to identify suitable analogs of homosalate and octisalate for use in a read-across safety assessment
LRSS Publications
Alternatives to Animal Testing

01 June 2024

Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion
LRSS Publications
Alternatives to Animal Testing

01 March 2024

Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene
LRSS Publications
Alternatives to Animal Testing

01 February 2024

Application of a skin and liver Chip2 microphysiological model to investigate the route-dependent toxicokinetics and toxicodynamics of consumer-relevant doses of genistein
LRSS Publications
Alternatives to Animal Testing

01 February 2023

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions
LRSS Publications
Alternatives to Animal Testing

01 January 2023

Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data
LRSS Publications
Alternatives to Animal Testing

01 October 2021

Demonstration of the first-pass metabolism in the skin of the hair dye, 4-amino-2-hydroxytoluene, using the Chip2 skin-liver microphysiological model
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